We report that in a cohort of 45,965 adults, who were receiving either the ChAdOx1 or the BNT162b2 SARS-CoV-2 vaccines, in those who had no prior infection with SARS-CoV-2, seroconversion rates and quantitative antibody levels after a single dose were lower in older individuals, especially in those aged >60 years. Two vaccine doses achieved high responses across all ages. Antibody levels increased more slowly and to lower levels with a single dose of ChAdOx1 compared with a single dose of BNT162b2, but waned following a single dose of BNT162b2 in older individuals. In descriptive latent class models, we identified four responder subgroups, including a ‘low responder’ group that more commonly consisted of people aged >75 years, males and individuals with long-term health conditions. Given our findings, we propose that available vaccines should be prioritized for those not previously infected and that second doses should be prioritized for individuals aged >60 years. Further data are needed to better understand the extent to which quantitative antibody responses are associated with vaccine-mediated protection. Longitudinal tracing of antibody responses to the ChAdOx1 and the BNT162b2 COVID-19 vaccines in 45,965 adults from the United Kingdom give indications for vaccine prioritization.
【저자키워드】 viral infection, Diagnostic markers, 【초록키워드】 Vaccine, COVID-19 vaccine, Antibody Response, SARS-CoV-2 vaccines, vaccine dose, BNT162b2, Adults, Cohort, Antibody responses, response, male, antibody levels, United Kingdom, longitudinal, Quantitative, ChAdOx1, single dose, antibody level, Older, second dose, subgroups, individual, indication, indications, long-term health conditions, quantitative antibody levels, seroconversion rates, seroconversion rate, receiving, individuals, had no, infection with SARS-CoV-2, latent class, of BNT162b2, quantitative antibody level, waned, 【제목키워드】 Antibody Response, SARS-CoV-2 vaccine, General population,