Mass spectrometry and some other biophysical methods, have made substantial contributions to the studies on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human proteins interactions. The most interesting feature of SARS-CoV-2 seems to be the structure of its spike (S) protein and its interaction with the human cell receptor. Mass spectrometry of spike S protein revealed how the glycoforms are distributed across the S protein surface. X-ray crystallography and cryo-electron microscopy made huge impact on the studies on the S protein and ACE2 receptor protein interaction, by elucidating the three-dimensional structures of these proteins and their conformational changes. The findings of the most recent studies in the scope of SARS-CoV-2-Human protein-protein interactions are described here.
【저자키워드】 glycosylation, MS, SARS Coronavirus, spike protein-ACE2 interaction, structural techniques, 【초록키워드】 SARS-CoV-2, coronavirus, mass spectrometry, S protein, Cryo-electron microscopy, X-ray crystallography, Protein, receptor, protein-protein interaction, interactions, Interaction, acute respiratory syndrome, three-dimensional structure, conformational changes, human cell, described, the S protein, ACE2 receptor protein, human protein, 【제목키워드】 Biology, technique, mass, Spectrometry,