It is not exactly clear yet which type of immune response prevails to accomplish viral clearance in coronavirus disease 2019 (COVID-19). Studying a patient with chronic lymphocytic leukemia and hypogammaglobulinemia who suffered from COVID-19 provided insight in the immunological responses after treatment with COVID-19 convalescent plasma (CCP). Treatment consisted of oxygen, repeated glucocorticosteroids and multiple dosages of CCP guided by antibody levels. Retrospectively performed humoral and cellular immunity analysis made clear that not every serological test for COVID-19 is appropriate for follow-up of sufficient neutralizing antibodies after CCP. In retrospect, we think that CCP merely bought time for this patient to develop an adequate cellular immune response which led to viral clearance and ultimately clinical recovery.
【저자키워드】 COVID-19, convalescent plasma, chronic lymphocytic leukemia, in vitro T cell assay, 【초록키워드】 Treatment, coronavirus disease, neutralizing antibody, serological test, immune response, antibody, Cellular immune response, oxygen, viral clearance, clinical recovery, cellular immunity, Patient, Follow-up, leukemia, Hypogammaglobulinemia, Immunological response, Analysis, humoral, CCP, dosage, repeated, performed, develop, provided, suffered, with COVID-19, 【제목키워드】 chronic, time, secondary,