The coronavirus disease 2019 (COVID-19) pandemic that has a significant rapid transmission is an international public health concern. Several dengue-endemic countries reported similar clinical and laboratory features between COVID-19 and dengue in the early incubation period, and thus discerning the infection is difficult. As a dengue-endemic country, Indonesia also poses the same challenge during the COVID-19 outbreak. This current study analyzed the IgG and IgM profiles from COVID-19 patients by using a serological SARS-CoV-2 and dengue rapid test. In addition, 38 sera from healthy individuals (pre-COVID-19 date) were analyzed using a dengue rapid test. Among 120 samples, 4 samples indicated dengue IgG positive. However, IgM, NS1, and RT-PCR analyses showed negative results. Interestingly, regarding seropositivity of NS1 and DENV IgG from healthy individuals (pre COVID-19 infection), two samples were positive DENV IgG, while one of them was positive NS1. This suggested that in the dengue-endemic area, many people have already experienced dengue and have immunity against dengue virus. There is also the possibility of antibody cross-reactivity between COVID-19 and dengue infection. This also emphasizes the high demand for a rapid method with high sensitivity and specificity that can distinguish between SARS-CoV-2 and dengue.
【저자키워드】 COVID-19, cross-reactivity, Dengue, SARS-CoV 2, rapid serological test, 【초록키워드】 coronavirus disease, SARS-CoV-2, IgG, IgM, pandemic, Immunity, Infection, Transmission, RT-PCR, COVID-19 outbreak, Rapid test, Sensitivity and specificity, COVID-19 infection, sera, Incubation period, Indonesia, dengue virus, serological, Analysis, COVID-19 patient, IgG and IgM, antibody cross-reactivity, profile, international public health, positive, country, analyzed, reported, indicated, addition, suggested, healthy individual, laboratory feature, 【제목키워드】 Test, Rapid, Misdiagnosis, Potential,