4-Hexylresorcinol (4HR) is amphiphilic organic chemical and auto-regulator for micro-organism. As 4HR administration induces the stress on the endoplasmic reticulum, 4HR changes protein folding. The application of 4HR inhibits NF-κB signal pathway and TNF-α production. In addition, 4HR administration increases VEGF, TGF-β1, and calcification associated proteins. As a consequence, 4HR administration increases angiogenesis and bone formation in wounded area. Strong anti-inflammatory reaction and capillary regeneration in diabetic model demonstrate that 4HR can be applied on many types of surgical wound.
All Keywords
【초록키워드】 Stress, Anti-inflammatory, Angiogenesis, Proteins, surgical, Endoplasmic reticulum, Protein, pathway, change, TNF-α, NF-κB, administration, Diabetic, TGF-β1, VEGF, addition, inhibit, increase, induce, Strong, 4-Hexylresorcinol, wounded, 【제목키워드】 wound healing, chaperone,
【초록키워드】 Stress, Anti-inflammatory, Angiogenesis, Proteins, surgical, Endoplasmic reticulum, Protein, pathway, change, TNF-α, NF-κB, administration, Diabetic, TGF-β1, VEGF, addition, inhibit, increase, induce, Strong, 4-Hexylresorcinol, wounded, 【제목키워드】 wound healing, chaperone,