Background: Co-infections of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with respiratory viruses, bacteria and fungi have been reported to cause a wide range of illness. Objectives: We assess the prevalence of co-infection of SARS-CoV-2 with seasonal respiratory viruses, document the respiratory viruses detected among individuals tested for SARS-CoV-2, and describe characteristics of individuals with respiratory virus co-infection detected. Methods: Specimens included in this study were submitted as part of routine clinical testing to Public Health Ontario Laboratory from individuals requiring testing for SARS-CoV-2 and/or seasonal respiratory viruses. Results: Co-infection was detected in a smaller proportion (2.5%) of individuals with laboratory confirmed SARS-CoV-2 than those with seasonal respiratory viruses (4.3%); this difference was not significant. Individuals with any respiratory virus co-infection were more likely to be younger than 65 years of age and male than those with single infection. Those with SARS-CoV-2 co-infection manifested mostly mild respiratory symptoms. Conclusions: Findings of this study may not support routine testing for seasonal respiratory viruses among all individuals tested for SARS-CoV-2, as they were rare during the study period nor associated with severe disease. However, testing for seasonal respiratory viruses should be performed in severely ill individuals, in which detection of other viruses may assist with patient management.
【저자키워드】 COVID-19, SARS-CoV-2, Co-infection, seasonal respiratory viruses, 【초록키워드】 viruses, coronavirus, Infection, severe acute respiratory syndrome Coronavirus, Laboratory, respiratory viruses, Prevalence, Characteristics, respiratory virus, management, male, Patient, Co-infection, age, Bacteria, respiratory, Patient management, fungi, severe disease, respiratory symptoms, Support, acute respiratory syndrome, not significant, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, individual, study period, clinical testing, finding, mild respiratory symptoms, Public, tested, performed, virus, respiratory virus, proportion, reported, submitted, individuals, manifested, assist, 【제목키워드】 viruses, respiratory, Canada, individual,