Objective: We assessed the magnitude of unidentified coronavirus disease 2019 (COVID-19) in our healthcare personnel (HCP) early in the COVID-19 pandemic, and we evaluated risk factors for infection to identify areas for improvement in infection control practice in a northern California academic medical center. Methods: We reviewed anti–severe acute respiratory coronavirus virus 2 (SARS-CoV-2) receptor-binding domain (RBD) IgG serologic test results and self-reported risk factors for seropositivity among 10,449 asymptomatic HCP who underwent voluntary serology testing between April 20 and May 20, 2020. Results: In total, 136 employees (1.3%) tested positive for SARS-CoV-2 IgG. This included 41 individuals (30.1%) who had previously tested positive for SARS-CoV-2 by nasopharyngeal reverse-transcription polymerase chain reaction (RT-PCR) between March 13 and April 16, 2020. In multivariable analysis, employees of Hispanic ethnicity (odds ratio [OR], 2.01; 95% confidence interval [CI], 1.22–3.46) and those working in environmental services, food services, or patient transport (OR, 4.81; 95% CI, 2.08–10.30) were at increased risk for seropositivity compared to other groups. Employees reporting a household contact with COVID-19 were also at higher risk for seropositivity (OR, 3.25; 95% CI, 1.47–6.44), but those with a work, exposure alone were not (OR, 1.27; 95% CI, 0.58–2.47). Importantly, one-third of seropositive individuals reported no prior symptoms, no suspected exposures, and no prior positive RT-PCR test. Conclusion: In this study, SARS-CoV-2 seropositivity among HCP early in the northern California epidemic appeared to be quite low and was more likely attributable to community rather than occupational exposure.
【초록키워드】 COVID-19, coronavirus disease, SARS-CoV-2, IgG, infection control, COVID-19 pandemic, Infection, risk factor, RT-PCR, virus, Symptoms, Epidemic, Asymptomatic, RBD, serology testing, nasopharyngeal, Patient, Community, SARS-CoV-2 IgG, positive RT-PCR, Odds ratio, Contact, healthcare personnel, Transport, higher risk, 95% CI, 95% confidence interval, increased risk, individual, domain, multivariable analysis, Hispanic ethnicity, positive, employee, hcp, Respiratory Coronavirus, polymerase chain, tested, identify, reported, evaluated, magnitude, groups, seropositive individual, with COVID-19, 【제목키워드】 COVID-19, coronavirus disease, SARS-CoV-2, pandemic, virus, healthcare personnel, Respiratory Coronavirus,