This study aimed to determine the relationships among hyperglycemia (HG), the presence of type 2 diabetes (T2D), and the outcomes of COVID-19. Demographic data, blood glucose levels (BG) measured on admission, and hospital outcomes of COVID-19 patients hospitalized at Boston University Medical Center from 1 March to 4 August 2020 were extracted from the hospital database. HG was defined as BG > 200 mg/dL. Patients with type 1 diabetes or BG < 70 mg/dL were excluded. A total of 458 patients with T2D and 976 patients without T2D were included in the study. The mean ± SD age was 56 ± 17 years and 642 (45%) were female. HG occurred in 193 (42%) and 42 (4%) of patients with and without T2D, respectively. Overall, the in-hospital mortality rate was 9%. Among patients without T2D, HG was statistically significantly associated with mortality, ICU admission, intubation, acute kidney injury, and severe sepsis/septic shock, after adjusting for potential confounders ( p < 0.05). However, only ICU admission and acute kidney injury were associated with HG among patients with T2D ( p < 0.05). Among the 235 patients with HG, the presence of T2D was associated with decreased odds of mortality, ICU admission, intubation, and severe sepsis/septic shock, after adjusting for potential confounders, including BG ( p < 0.05). In conclusion, HG in the subset of patients without T2D could be a strong indicator of high inflammatory burden, leading to a higher risk of severe COVID-19.
【저자키워드】 COVID-19, SARS-CoV-2, coronavirus, Mortality, Type 2 diabetes mellitus, hyperglycemia, blood glucose, 【초록키워드】 Hospitalized, severe COVID-19, hospital, intubation, Acute kidney injury, outcome, database, Shock, female, Patient, ICU admission, age, demographic, university, Admission, Inflammatory, COVID-19 patient, T2D, higher risk, in-hospital mortality rate, confounders, center, Boston, confounder, defined, occurred, significantly, determine, subset, diabete, statistically, type 2 diabete, were excluded, 【제목키워드】 presentation, Type,