Vitamin D and zinc are important components of nutritional immunity. This study compared the serum concentrations of 25-hydroxyvitamin D (25(OH)D) and zinc in COVID-19 outpatients with those of potentially non-infected participants. The association of clinical symptoms with vitamin D and zinc status was also examined. A checklist and laboratory examination were applied to collect data in a cross-sectional study conducted on 53 infected outpatients with COVID-19 and 53 potentially non-infected participants. Serum concentration of 25(OH)D were not significantly lower in patients with moderate illness (19 ± 12 ng/mL) than patients with asymptomatic or mild illness (29 ± 18 ng/mL), with a trend noted for a lower serum concentration of 25(OH)D in moderate than asymptomatic or mild illness patients ( p = 0.054). Infected patients (101 ± 18 µg/dL) showed a lower serum concentration of zinc than potentially non-infected participants (114 ± 13 µg/dL) ( p = 0.01). Patients with normal (odds ratio (OR), 0.19; p ≤ 0.001) and insufficient (OR, 0.3; p = 0.007) vitamin D status at the second to seventh days of disease had decreased OR of general symptoms compared to patients with vitamin D deficiency. This study revealed the importance of 25(OH)D measurement to predict the progression of general and pulmonary symptoms and showed that infected patients had significantly lower zinc concentrations than potentially non-infected participants.
【저자키워드】 COVID-19, Clinical symptoms, Vitamin D status, sunlight exposure, zinc status, 【초록키워드】 Immunity, Vitamin D, cross-sectional, 25-hydroxyvitamin D, Symptom, progression, Laboratory, serum, Asymptomatic, Patient, disease, moderate, predict, association, Outpatient, Concentration, Odds ratio, deficiency, Participants, clinical symptom, participant, component, mild illness, significantly lower, non-infected, examined, conducted, applied, infected patient, COVID-19 outpatient, patients with asymptomatic, patients with moderate, pulmonary symptom, with COVID-19, 【제목키워드】 SARS-CoV-2, Zinc, Vitamin D, clinical, Outpatient, status,