Historically, vitamin D is recognized as an essential component for the maintenance of the musculoskeletal system. The immunomodulatory role of vitamin D in health and disease has gained much interest in recent years due to the many pathologies that share underlying immunological features where vitamin D has been shown to exert a potential role. Evidence from pre-clinical studies show that vitamin D elicits biological effects on both the innate and adaptive immune systems. Furthermore, in vivo studies have shown that administration of vitamin D can lead to changes in or the development of a range of immune-related diseases. This encourages the hypothesis that data derived from clinical and epidemiological studies connect vitamin D with the incidence and severity of many immune-mediated disorders such as rheumatoid arthritis, diabetes, and infectious diseases. Since some other immune-mediated diseases share similar features to that of viral infection such as COVID-19, in this review, we examined these other areas and the role of vitamin D in these diseases.
【저자키워드】 COVID-19, Vitamin D, cholecalciferol, immune-mediated disease, 【초록키워드】 pathology, viral infection, Diseases, adaptive, severity, diabetes, rheumatoid arthritis, Health, immunomodulatory, incidence, in vivo, disease, Immune-mediated, Hypothesis, administration, Musculoskeletal, Epidemiological study, disorder, immune systems, Effect, immunological, feature, shown, examined, changes in, elicit, immune-related diseases, 【제목키워드】 profile, opinion, Immunologic, role, expert,