Background Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) infection elicits inflammatory manifestations that relate with a “cytokine storm.” Objective The aim of this research was to assess the role of circulating interleukin 6 (IL-6) levels and other inflammatory markers in patients with coronavirus disease 2019 (COVID-19) on metabolic functions and accompanying clinical complications. Patients and Methods . A total of 165 patients diagnosed with COVID-19 pneumonia were examined for medical features and inflammatory markers such as blood IL-6, CRP, ferritin, LDH, neutrophil/lymphocyte index (NLI), D-Dimer, and Red Cell Distribution Width (RDW). Regression analyses concerning electronically collected medical data were adjusted by appropriate factors and confounding variables . Results . Plasma IL-6 determinations evidenced a consistent association with hospital stay days, Intensive Care Unit (ICU) admission, and mortality rates. Similar trends were found for other proinflammatory variables, where ferritin and NLI showed a remarkable value as surrogates. Hyperglycaemia and the Charlson Comorbidity Index Score were positively associated with the inflammatory response induced by the SARS-COV-2 infection. An unhealthy lifestyle such as smoking and alcoholic drinks consumption as well as excessive body adiposity influenced inflammatory-related outcomes in the screened patients. Conclusion IL-6 together with other inflammatory biomarkers accompanied poor clinical and metabolic outcomes in COVID-19-infected patients. IL-6 may result in a suitable proxy to individually categorise patients in order to manage this infectious pandemic.
【초록키워드】 COVID-19, coronavirus disease, pandemic, Pneumonia, IL-6, Infection, intensive care unit, LDH, CRP, ferritin, outcome, smoking, coronavirus 2, ICU, proinflammatory, Adiposity, Research, Patient, Inflammatory marker, respiratory, mortality rates, Admission, patients, score, Blood, association, Inflammatory biomarker, Inflammatory response, Analysis, Inflammatory, Regression, manifestation, Hospital stay, Factor, confounding variable, metabolic function, Charlson Comorbidity Index, circulating, width, clinical complications, objective, feature, Result, collected, examined, screened, adjusted, elicit, evidenced, concerning, accompanied, categorise, diagnosed with COVID-19, Red, variables, 【제목키워드】 COVID-19, clinical, metabolic,