Background Coagulopathy and thromboembolic events are among the complications of Corona Virus disease 2019 (COVID-19). Abnormal coagulation parameters in COVID-19 patients are important prognostic factors of disease severity. The aim of this study was to analyze coagulation profiles of hospitalized COVID-19 patients in Addis Ababa, Ethiopia. Methods This prospective cross-sectional study was conducted among 455 Covid-19 patients admitted at Millennium COVID-19 care and treatment center, Addis Ababa, Ethiopia from July 1- October 23, 2020. Prothrombin Time (PT), Activated Partial Thromboplastin Time (APTT) and International normalized ratio (INR) were determined on HUMACLOT DUE PLUS® coagulation analyzer (Wiesbaden, Germany). In all statistical analysis of results, p<0.05 was defined as statistically significant. Result A prolonged prothrombin time was found in 46.8% of study participants with COVID-19 and a prolonged prothrombin time and elevated INR in 53.3% of study subjects with severe and 51% of critically COVID patients. Thrombocytopenia was detected in 22.1% of COVID-19 patients. 50.5% and 51.3% of COVID-19 patients older than 55 years had thrombocytopenia and prolonged APTT respectively. Conclusion In this study, prolonged prothrombin time and elevated INR were detected in more than 50% of severe and critical COVID-19 patients. Thrombocytopenia and prolonged APTT were dominant in COVID-19 patients older than 55 years. Thus, we recommend emphasis to be given for monitoring of platelet count, PT, APTT and INR in hospitalized and admitted COVID-19 patients.
【초록키워드】 COVID-19, Treatment, Hospitalized, cross-sectional, disease severity, Coagulation, Coagulopathy, cross-sectional study, Corona, Germany, Patient, Platelet, Complication, thrombocytopenia, disease, Care, prothrombin, COVID-19 patients, Platelet count, hospitalized COVID-19 patient, statistical analysis, COVID-19 patient, Prognostic factor, Prothrombin time, Virus Disease, partial thromboplastin time, international normalized ratio, activated partial thromboplastin time, thromboembolic, Older, Thromboembolic events, hospitalized COVID-19 patients, profile, subject, abnormal coagulation, aPTT, Study participants, THROMBOPLASTIN, Covid patients, critical COVID-19 patients, Wiesbaden, dominant, Thromboembolic event, time, Result, defined, Partial, elevated, conducted, statistically significant, study participant, coagulation parameter, INR, normalized, with COVID-19, 【제목키워드】 COVID-19, abnormality, parameter, hospitalized patient,