Background Recent studies reported that patients with coronavirus disease-2019 (COVID-19) might have liver injury. However, few data on the combined analysis and change patterns of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin (TBil) have been shown. Methods This is a single-center retrospective study. A total of 105 adult patients hospitalized for confirmed COVID-19 in Beijing Ditan Hospital between January 12, and March 17, 2020 were included, and divided into mild group ( n = 79) and severe group( n = 26). We compared liver functional test results between the two groups. Category of ALT change during the disease course was also examined. Results 56.2% (59/105) of the patients had unnormal ALT, AST, or total TBil throughout the course of the disease, but in 91.4% (96/105) cases the level of ALT, AST or TBil ≤3 fold of the upper limit of normal reference range (ULN). The overall distribution of ALT, AST, and TBil were all significantly difference between mild and severe group ( P < 0.05). The percentage of the patients with elevated both ALT and AST was 12.7% (10/79) in mild cases vs. 46.2% (12/26) in severe cases ( P = 0.001). 34.6% (9/26) severe group patients started to have abnormal ALT after admission, and 73.3% (77/105) of all patients had normal ALT before discharge. Conclusions Elevated liver function index is very common in patients with COVID-19 infection, and the level were less than 3 × ULN, but most are reversible. The abnormality of 2 or more indexes is low in the patients with COVID-19, but it is more likely to occur in the severe group.
【저자키워드】 coronavirus disease-2019, Liver function, Dynamic change, 【초록키워드】 COVID-19, coronavirus, Infection, discharge, Retrospective study, Patient, Aspartate aminotransferase, Liver injury, AST, Mild, distribution, Admission, liver, ALT, Analysis, alanine aminotransferase, two groups, total bilirubin, severe group, Beijing, single-center, Severe case, abnormality, recent, limit, Course, Result, shown, examined, significantly, reported, the patient, the disease, elevated, functional, less, occur, mild case, patients hospitalized, patients with COVID-19, ULN, with COVID-19, 【제목키워드】 Patient, Liver injury, Retrospective analysis, pattern, 105 patient,