Abstract The novel SARS‐coronavirus 2 (SARS‐CoV‐2) poses a global challenge on healthcare and society. For understanding the susceptibility for SARS‐CoV‐2 infection, the cell type‐specific expression of the host cell surface receptor is necessary. The key protein suggested to be involved in host cell entry is angiotensin I converting enzyme 2 (ACE2). Here, we report the expression pattern of ACE2 across > 150 different cell types corresponding to all major human tissues and organs based on stringent immunohistochemical analysis. The results were compared with several datasets both on the mRNA and protein level. ACE2 expression was mainly observed in enterocytes, renal tubules, gallbladder, cardiomyocytes, male reproductive cells, placental trophoblasts, ductal cells, eye, and vasculature. In the respiratory system, the expression was limited, with no or only low expression in a subset of cells in a few individuals, observed by one antibody only. Our data constitute an important resource for further studies on SARS‐CoV‐2 host cell entry, in order to understand the biology of the disease and to aid in the development of effective treatments to the viral infection. The protein expression profile of ACE2, suggested as host receptor for SARS‐CoV‐2, is assessed in various human organs. Notably, limited ACE2 expression is observed in the respiratory system both on the protein and mRNA level.
【저자키워드】 immunohistochemistry, ACE2, transcriptomics, Microbiology, Virology & Host Pathogen Interaction, Respiratory system, Methods & Resources, SARS‐CoV-2, 【초록키워드】 Treatment, viral infection, antibody, susceptibility, SARS‐CoV‐2, Protein, cells, mRNA, healthcare, male, placental, dataset, vasculature, receptor, resource, ACE2 expression, expression, Analysis, enterocytes, ductal cells, cell type, host cell, enzyme, host receptor, low expression, protein expression, SARS‐CoV‐2 infection, organs, protein level, renal, organ, expression pattern, mRNA level, Gallbladder, effective, Cell, host cell surface, involved, the disease, human tissue, suggested, individuals, subset, reproductive, 【제목키워드】 protein expression, human tissue,