Coronavirus Disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Like the 2002–2003 epidemic severe acute respiratory syndrome coronavirus (SARS-CoV), angiotensin converting enzyme-2 (ACE-2) has been identified as the SARS-CoV-2 receptor. 1 – 3 The virus docks into host cell via its spike protein binding to ACE-2 and undergoes proteolytic cleavage by TMPRSS2 protease to facilitate membrane fusion. The spike protein binding to ACE-2 has been shown to be stronger in the novel SARS-CoV-2 virus. 1 This review will present an overview of ACE-2 biology.
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【저자키워드】 COVID-19, SARS-CoV-2, Lung injury, renin angiotensin system, angiotensin converting enzyme-2 (ACE-2), 【초록키워드】 coronavirus, SARS-CoV, virus, Spike protein, Angiotensin converting enzyme-2, ACE-2, Epidemic, membrane fusion, receptor, binding, host cell, acute respiratory syndrome, novel SARS-CoV-2 virus, TMPRSS2 protease, proteolytic cleavage, shown, caused, facilitate, Like, the SARS-CoV-2, 【제목키워드】 ACE-2, Research, disease, angiotensin,
【저자키워드】 COVID-19, SARS-CoV-2, Lung injury, renin angiotensin system, angiotensin converting enzyme-2 (ACE-2), 【초록키워드】 coronavirus, SARS-CoV, virus, Spike protein, Angiotensin converting enzyme-2, ACE-2, Epidemic, membrane fusion, receptor, binding, host cell, acute respiratory syndrome, novel SARS-CoV-2 virus, TMPRSS2 protease, proteolytic cleavage, shown, caused, facilitate, Like, the SARS-CoV-2, 【제목키워드】 ACE-2, Research, disease, angiotensin,