Abstract The Reactome Knowledgebase ( https://reactome.org ), an Elixir core resource, provides manually curated molecular details across a broad range of physiological and pathological biological processes in humans, including both hereditary and acquired disease processes. The processes are annotated as an ordered network of molecular transformations in a single consistent data model. Reactome thus functions both as a digital archive of manually curated human biological processes and as a tool for discovering functional relationships in data such as gene expression profiles or somatic mutation catalogs from tumor cells. Recent curation work has expanded our annotations of normal and disease-associated signaling processes and of the drugs that target them, in particular infections caused by the SARS-CoV-1 and SARS-CoV-2 coronaviruses and the host response to infection. New tools support better simultaneous analysis of high-throughput data from multiple sources and the placement of understudied (‘dark’) proteins from analyzed datasets in the context of Reactome’s manually curated pathways.
【초록키워드】 SARS-CoV-2, coronavirus, Mutation, Infection, host response, drug, SARS-CoV-1, Protein, humans, dataset, molecular, resource, function, Signaling, Analysis, Pathways, tumor cells, physiological, Support, acquired disease, annotation, gene expression profile, ELIXIR, recent, analyzed, caused, functional, provide, disease-associated, New, biological processe, curated, 【제목키워드】 pathway,