Clinical publications show consistently that headache is a common symptom in the coronavirus disease of 2019 (COVID-19). Several studies specifically investigated headache symptomatology and associated features in patients with COVID-19. The headache is frequently debilitating with manifold characters including migraine-like characteristics. Studies suggested that COVID-19 patients with headache vs. those without headache are more likely to have anosmia. We present a pathophysiological hypothesis which may explain this phenomenon, discuss current hypotheses about how the coronavirus SARS-CoV-2 enters the central nervous system and suggest that activation of the trigeminal nerve may contribute to both headache and anosmia in COVID-19.
【저자키워드】 coronavirus disease, headache, Anosmia, olfactory, trigeminal, 【초록키워드】 COVID-19, Symptom, coronavirus SARS-CoV-2, Characteristics, clinical, Central nervous system, Hypothesis, COVID-19 patient, Activation, feature, investigated, contribute, suggested, explain, hypothese, pathophysiological, patients with COVID-19, 【제목키워드】 COVID-19, SARS-CoV-2, contribute,