Background The COVID-19 pandemic has drastically affected everyone in a hit or miss manner. Since it began, evidence of the neuro-invasive potential of the virus has been intensifying significantly. Several pathways have been hypothesized to elucidate the neurotropic nature of SARS-CoV2. It is the need of the hour to collect vital information. Objective To evaluate and correlate the neuro-radiological and neurological manifestations in patients diagnosed with SARS-CoV2. To identify neuro-invasive pathways of COVID infection. Methods Relevant studies were identified through four databases—the Cochrane Library, PubMed, Science Direct, and Web of Science. These were searched using relevant keywords—“COVID-19,” “SARS-CoV2,” “neurological manifestations,” “neuroimaging,” “CT,” and “MRI.” Relevant articles were screened according to a pre-defined inclusion and exclusion criteria from December 2019 to August 2020. Results Our review included a total of 63 full text publications with 584 patients, composed mainly of observational studies, case reports, and case series. The most common neurological manifestations associated with COVID-19 were altered mental status, stroke, and paralysis. About 17.85% patients who underwent neuroimaging were found to be having ischemic changes suggestive of a stroke. This was followed by hemorrhagic changes as the second most common finding. The most commonly involved vessel was the Middle Cerebral Artery. Besides stroke, we found that SARS-CoV2 could be the cause for new-onset seizures, Guillain-Barre Syndrome, encephalitis, and many other severe neurological diseases. Conclusion The information that we have obtained so far will prove dynamic to healthcare providers working against the COVID-19 pandemic. It is necessary to be aware of these atypical neurological findings for the early diagnosis and treatment of COVID-19 infected patients. However, to completely understand the connection between SARS-CoV2 and the nervous system, further research is necessary.
【저자키워드】 COVID-19, stroke, Neuroimaging, SARS-CoV 2, Neuro-invasive, 【초록키워드】 Treatment, SARS-CoV2, COVID-19 pandemic, Infection, virus, observational studies, Encephalitis, COVID, early diagnosis, Case series, Research, Patient, pathway, nervous system, information, change, patients, Evidence, cerebral, Atypical, neurological, Altered mental status, Seizures, Artery, exclusion criteria, Science, Hemorrhagic, connection, Healthcare provider, Web of Science, Cochrane Library, article, Neurological diseases, paralysis, middle, COVID-19 infected patients, Inclusion, Direct, neurological manifestation, objective, vessel, neurotropic, Result, identify, affected, evaluate, significantly, involved, composed, diagnosed, screened, searched, with COVID-19, 【제목키워드】 systematic review, Patient, manifestation,