Background: The COVID-19 pandemic poses an imminent threat to humanity, especially for those who have comorbidities. Evidence of COVID-19 and COPD comorbidities is accumulating. However, data revealing the molecular mechanism of COVID-19 and COPD comorbid diseases is limited. Methods: We got COVID-19/COPD -related genes from different databases by restricted screening conditions (top500), respectively, and then supplemented with COVID-19/COPD-associated genes (FDR<0.05, |LogFC|≥1) from clinical sample data sets. By taking the intersection, 42 co-morbid host factors for COVID-19 and COPD were finally obtained. On the basis of shared host factors, we conducted a series of bioinformatics analysis, including protein-protein interaction analysis, gene ontology and pathway enrichment analysis, transcription factor-gene interaction network analysis, gene-microRNA co-regulatory network analysis, tissue-specific enrichment analysis and candidate drug prediction. Results: We revealed the comorbidity mechanism of COVID-19 and COPD from the perspective of host factor interaction, obtained the top ten gene and 3 modules with different biological functions. Furthermore, we have obtained the signaling pathways and concluded that dexamethasone, estradiol, progesterone, and nitric oxide shows effective interventions. Conclusion: This study revealed host factor interaction networks for COVID-19 and COPD, which could confirm the potential drugs for treating the comorbidity, ultimately, enhancing the management of the respiratory disease.
【저자키워드】 COVID-19, Comorbidity, COPD, host factor interaction networks, bioinformatics analyses, 【초록키워드】 Dexamethasone, Biological functions, nitric oxide, COVID-19 pandemic, Transcription, Comorbidities, drug, molecular mechanism, database, management, Respiratory disease, Ontology, Factors, network analysis, signaling pathway, Bioinformatics analysis, enrichment analysis, protein-protein interaction, mechanism, Interaction, Analysis, Pathway enrichment analysis, evidence of, data sets, progesterone, Factor, Perspective, effective interventions, Intersection, Host, comorbid disease, conducted, condition, accumulating, 【제목키워드】 network, Factor, Identified,