Severe Acute Respiratory Syndrome Coronavirus—2 (SARS CoV-2) has resulted in the global spread of Coronavirus Disease 2019 (COVID-19) and an increase in complications including Acute Respiratory Distress Syndrome (ARDS). Due to the lack of therapeutic options for Acute Respiratory Distress Syndrome, recent attention has focused on differentiating hyper- and hypo-inflammatory phenotypes of ARDS to help define effective therapeutic strategies. Interleukin 8 (IL-8) is a pro-inflammatory cytokine that has a role in neutrophil activation and has been identified within the pathogenesis and progression of this disease. The aim of this review is to highlight the role of IL-8 as a biomarker and prognostic factor in modulating the hyperinflammatory response in ARDS. The crucial role of IL-8 in lung inflammation and disease pathogenesis might suggest IL-8 as a possible new therapeutic target to efficiently modulate the hyperinflammatory response in ARDS.
【저자키워드】 COVID-19, Neutrophils, ARDS, Cytokine storm, NETs, Interleukin 8 (IL-8), CXCR1/2, 【초록키워드】 SARS CoV-2, Biomarker, Pathogenesis, progression, Spread, interleukin, Therapeutic strategies, IL-8, Complication, phenotype, respiratory, disease, Lung inflammation, therapeutic target, neutrophil activation, Prognostic factor, therapeutic option, disease pathogenesis, help, pro-inflammatory cytokine, Hyperinflammatory, effective, highlight, lack, modulate, increase in, modulating, 【제목키워드】 interleukin-8, respiratory, role,