The novel and highly pathogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), has become a continued focus of global attention due to the serious threat it poses to public health. There are no specific drugs available to combat SARS-CoV-2 infection. Natural products (carolacton, homoharringtonine, emetine, and cepharanthine) and natural product-inspired small molecules (ivermectin, GS-5734, EIDD-2801, and ebselen) are potential anti-SARS-CoV-2 agents that have attracted significant attention due to their broad-spectrum antiviral activities. Here, we review the research on potential landmark anti-SARS-CoV-2 agents, systematically discussing the importance of natural products and natural-product-inspired small molecules in the research and development of safe and effective antiviral agents.
【저자키워드】 COVID-19, SARS-CoV-2, natural products, natural-product-inspired, potential anti-SARSCoV-2 agents, 【초록키워드】 Ivermectin, coronavirus disease, public health, coronavirus, SARS-COV-2 infection, drug, anti-SARS-CoV-2, Antiviral agents, Research, EIDD-2801, Ebselen, small molecule, GS-5734, Safe, antiviral activities, homoharringtonine, natural, acute respiratory syndrome, highly pathogenic, effective, cause, 【제목키워드】 Chemical, natural, product, counter, Potential, Turning,