Novel coronavirus disease (COVID-19) pandemic caused by SARS-CoV-2, for which there is no effective treatment except employing prevention strategies, has already instituted significant number of deaths. In this review, we provide a scientific view on the potential role of vitamin D in SARS-CoV-2 virus/COVID-19 disease. Vitamin D is well-known to play a significant role in maintaining the immune health of an individual. Moreover, it induces antimicrobial peptide expression that can decrease viral replication and regulate the levels of pro-inflammatory/anti-inflammatory cytokines. Therefore, supplementation of vitamin D has the potential to reduce the incidence, severity and the risk of death from pneumonia resulting from the cytokine storm of many viral infections including COVID-19. We suggest that supplementation of subjects at high risk of COVID-19 with vitamin D (1.000 to 3.000 IU) to maintain its optimum serum concentrations may be of significant benefit for both in the prevention and treatment of the COVID-19.
【저자키워드】 SARS-CoV-2, respiratory tract infection, COVID 19, Vitamin D3, vitamin D3 receptor, 【초록키워드】 COVID-19, Treatment, coronavirus disease, viral infection, pandemic, Cytokines, Vitamin D, Pneumonia, severity, serum, viral replication, incidence, novel, disease, expression, Concentration, regulate, deaths, high risk, risk of death, subject, antimicrobial peptide, effective, benefit, immune health, decrease, resulting, caused, maintain, induce, reduce, the cytokine storm, 【제목키워드】 COVID-19, Vitamin,