Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is an enveloped, single-stranded RNA virus. Humans infected with SARS-CoV-2 develop a disease known as coronavirus disease 2019 (COVID-19) with symptoms and consequences including acute respiratory distress syndrome (ARDS), cardiovascular disorders, and death. SARS-CoV-2 appears to infect cells by first binding viral spike proteins with host protein angiotensin-converting enzyme 2 (ACE2) receptors; the virus is endocytosed following priming by transmembrane protease serine 2 (TMPRSS2). The process of virus entry into endosomes and its release from endolysosomes are key features of enveloped viruses. Thus, it is important to focus attention on the role of endolysosomes in SARS-CoV-2 infection. Indeed, coronaviruses are now known to hijack endocytic machinery to enter cells such that they can deliver their genome at replication sites without initiating host detection and immunological responses. Hence, endolysosomes might be good targets for developing therapeutic strategies against coronaviruses. Here, we focus attention on the involvement of endolysosomes in SARS-CoV-2 infection and COVID-19 pathogenesis. Further, we explore endolysosome-based therapeutic strategies to restrict SARS-CoV-2 infection and COVID-19 pathogenesis.
【저자키워드】 endocytosis, endolysosome, two pore channel, 【초록키워드】 COVID-19, coronavirus disease, viruses, SARS-CoV-2, ACE2, ARDS, TMPRSS2, Coronaviruses, SARS-COV-2 infection, Human, Genome, Symptom, protease, virus, angiotensin-converting enzyme 2, COVID-19 pathogenesis, Cardiovascular disorders, virus entry, immunological responses, death, target, disease, therapeutic strategy, binding, acute respiratory distress, Coronavirus-2, endosome, viral spike protein, acute respiratory syndrome, syndrome, host protein, transmembrane, priming, single-stranded RNA virus, serine 2, Host, feature, Cell, consequence, develop, appear, coronavirus, restrict, endocytic, endocytosed, infect cell, infected with SARS-CoV-2, replication site, 【제목키워드】 respiratory, role, Potential,