Summary Background In high-income countries, mortality related to hospitalized patients with the Coronavirus disease 2019 (COVID-19) is approximately 4–5%. However, data on COVID-19 admissions from sub-Saharan Africa are scanty. Objective To describe the clinical profile and determinants of outcomes of patients with confirmed COVID-19 admitted at a hospital in Ghana. Methods A prospective study involving 25 patients with real time polymerase chain reaction confirmed COVID-19 admitted to the treatment centre of the University Hospital, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana from 1 st June to 27 th July, 2020. They were managed and followed up for outcomes. Data were analysed descriptively, and predictors of mortality assessed using a multivariate logistic regression modelling. Results The mean age of the patients was 59.3 ± 20.6 years, and 14 (56%) were males. The main symptoms at presentation were breathlessness (68%) followed by fever (56%). The cases were categorized as mild (6), moderate (6), severe (10) and critical (3). Hypertension was the commonest comorbidity present in 72% of patients. Medications used in patient management included dexamethasone (68%), azithromycin (96%), and hydroxychloroquine (4%). Five of 25 cases died (Case fatality ratio 20%). Increasing age and high systolic blood pressure were associated with mortality. Conclusion Case fatality in this sample of hospitalized COVID-19 patients was high. Thorough clinical assessment, severity stratification, aggressive management of underlying co-morbidities and standardized protocols incountry might improve outcomes. Funding None declared
【저자키워드】 COVID-19, Hospitalized, outcomes, clinical, Ghana, 【초록키워드】 Dexamethasone, Treatment, Stratification, Coronavirus disease 2019, Mortality, Hydroxychloroquine, severity, hospital, technology, Prospective Study, Comorbidity, Symptom, outcome, sub-Saharan Africa, management, Fever, Patient, co-morbidity, Mild, age, predictor, university, Critical, moderate, patients, funding, fatality, hospitalized COVID-19 patient, real time, Science, determinant, breathlessness, Systolic blood pressure, multivariate logistic regression, COVID-19 admission, standardized protocol, objective, males, polymerase chain, IMPROVE, Result, died, the patient, analysed, hospitalized patient, Increasing, KNUST, Kwame Nkrumah, 【제목키워드】 hospital, outcome, profile, hospitalized patient, with COVID-19,