Coronavirus disease (COVID-19) rapidly progresses to severe acute respiratory syndrome. This review aimed at collating available data on COVID-19 infection in solid organ transplantation (SOT) patients. We performed a systematic review of SOT patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The MEDLINE and PubMed databases were electronically searched and updated until April 20, 2020. The MeSH terms used were “COVID-19” AND “Transplant.” Thirty-nine COVID-19 cases were reported among SOT patients. The median interval for developing SARS-CoV-2 infection was 4 years since transplantation, and the fatality rate was 25.64% (10/39). Sixteen cases were described in liver transplant (LT) patients, and the median interval since transplantation was 5 years. The fatality rate among LT patients was 37.5% (6/16), with death occurring more than 3 years after LT. The youngest patient who died was 59 years old; there were no deaths among children. Twenty-three cases were described in kidney transplant (KT) patients. The median interval since transplantation was 4 years, and the fatality rate was 17.4% (4/23). The youngest patient who died was 71 years old. Among all transplant patients, COVID-19 had the highest fatality rate in patients older than 60 years : LT, 62.5% vs 12.5% ( p =0.006); KT 44.44% vs 0 ( p =0.039); and SOT, 52.94% vs 4.54% ( p =0.001). This study presents a novel description of COVID-19 in abdominal SOT recipients. Furthermore, we alert medical professionals to the higher fatality risk in patients older than 60 years. (PROSPERO, registration number=CRD42020181299)
【저자키워드】 COVID-19, SARS-CoV-2, 2019-nCoV, systematic review, liver diseases, humans, Liver transplantation, solid organ transplant recipient, 【초록키워드】 coronavirus, SARS-COV-2 infection, children, solid organ transplantation, risk, database, COVID-19 infection, Patient, death, disease, liver, patients, kidney transplant, fatality, SOT, acute respiratory syndrome, available data, recipients, COVID-19 case, Fatality rate, professional, median interval, highest, described, performed, died, reported, searched, MeSH term, patients older, SOT patient, SOT patients, the median, 【제목키워드】 solid organ transplantation,