Background Coronavirus disease 2019 (COVID-19) has rapidly spread worldwide. Systematic analysis of lung cancer survivors at molecular and clinical levels is warranted to understand the disease course and clinical characteristics. Methods A single-center, retrospective cohort study was conducted in 65 patients with COVID-19 from Wuhan Huoshenshan Hospital, of which 13 patients were diagnosed with lung cancer. The study was conducted from February 4 to April 11, 2020. Results During the course of treatment, lung cancer survivors infected with severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) had shorter median time from symptom onset to hospitalization ( P = 0.016) and longer clinical symptom remission time ( P = 0.020) than non-cancer individuals. No differences were observed among indicators such as time from symptom onset to hospitalization and symptom remission time between medium-term and short-term survivors. The expression of ACE2 ( P = 0.013) and TMPRSS2 ( P < 0.001) was elevated in lung cancer survivors as compared with that in non-cancer individuals. Conclusions ACE2 and TMPRSS2 levels were higher at resection margins of lung cancer survivors than those in normal tissues of non-cancerous individuals and may serve as factors responsible for the high susceptibility to COVID-19 among lung cancer survivors. Lung cancer patients diagnosed with COVID-19, including medium-term survivors, have worse outcomes than the general population.
【저자키워드】 COVID-19, ACE2, lung cancer, Single Cell, TMPRSS2, 【초록키워드】 Treatment, Coronavirus disease 2019, ACE2, coronavirus, Hospitalization, Clinical characteristics, susceptibility, Symptom, outcome, Spread, Survivors, Wuhan, Patient, General population, molecular, expression, margin, Analysis, cancer patient, symptom onset, retrospective cohort study, acute respiratory syndrome, Factor, tissue, median time, clinical symptom, individual, single-center, Huoshenshan Hospital, survivor, TMPRSS2 level, Course, Result, responsible, diagnosed, the disease, elevated, conducted, individuals, diagnosed with COVID-19, non-cancerous, patients with COVID-19, 【제목키워드】 SARS-CoV-2, ACE2, Resection,