ABSTRACT Lymphoid tissue returns to a steady state once each immune response is resolved, and although this occurs multiple times throughout life, its structural integrity and functionality remain unaffected. Stromal cells orchestrate cellular interactions within lymphoid tissue, and any changes to the microenvironment can have detrimental outcomes and drive disease. A breakdown in lymphoid tissue homeostasis can lead to a loss of tissue structure and function that can cause aberrant immune responses. This Review highlights recent advances in our understanding of lymphoid tissue function and remodelling in adaptive immunity and in disease states. We discuss the functional role of lymphoid tissue in disease progression and explore the changes to lymphoid tissue structure and function driven by infection, chronic inflammatory conditions and cancer. Understanding the role of lymphoid tissues in immune responses to a wide range of pathologies allows us to take a fuller systemic view of disease progression. Summary: Lymphoid tissue fitness can determine disease severity and affect outcome by altering the course of immune responses. We discuss how lymphoid tissue function can impact disease progression during infections, chronic inflammatory conditions and cancer.
【저자키워드】 homeostasis, stromal cells, Fibroblastic reticular cells, Lymphoid tissue, 【초록키워드】 review, pathology, immune response, adaptive, Immunity, disease severity, Cancer, Infection, outcome, Disease progression, infections, immune responses, understanding, disease, change, detrimental, Steady state, tissue, microenvironment, inflammatory condition, Affect, Cell, highlight, Course, functional, determine, occur, driven by, resolved, aberrant immune responses, cellular interaction, 【제목키워드】 Efficacy, dysfunction,