ABSTRACT HCoV-OC43 is one of the mildly pathogenic coronaviruses with high infection rates in common population. Here, 43 HCoV-OC43 related cases with pneumonia were reported, corresponding genomes of HCoV-OC43 were obtained. Phylogenetic analyses based on complete genome, orf1ab and spike genes revealed that two novel genotypes of HCoV-OC43 have emerged in China. Obvious recombinant events also can be detected in the analysis of the evolutionary dynamics of novel HCoV-OC43 genotypes. Estimated divergence time analysis indicated that the two novel genotypes had apparently independent evolutionary routes. Efforts should be conducted for further investigation of genomic diversity and evolution analysis of mildly pathogenic coronaviruses.
【저자키워드】 Pneumonia, HCoV-OC43, Hospitalized children, recombinant, novel genotype, 【초록키워드】 Evolution, Genome, China, spike gene, Genotype, evolutionary dynamics, infection rate, genotypes, genomic, Analysis, pathogenic coronaviruses, Complete, event, independent, reported, indicated, conducted, analysis, Estimated, pathogenic coronavirus, 【제목키워드】 Hospitalized, children, China, Genotype, human coronavirus OC43, circulating,