Two herds of dromedary camels were longitudinally sampled with nasal and rectal swabs and serum, between September 2014 and May 2015, and the samples were tested for Middle East Respiratory Syndrome (MERS) coronavirus RNA and antibodies. Evidence of MERS-CoV infection was confirmed in one herd on the basis of detection of virus RNA in nasal swabs from three camels and significant increases in the antibody titers from three others. The three viruses were genetically identical, thus indicating introduction of a single virus into this herd. There was evidence of reinfection of camels that were previously seropositive, thus suggesting that prior infection does not provide complete immunity from reinfection, a finding that is relevant to camel vaccination strategies as a means to prevent zoonotic transmission.
【저자키워드】 coronavirus, Immunity, Reinfection, Cohort, MERS coronavirus, Camel, Dromedary, 【초록키워드】 antibodies, Infection, nasal, MERS, virus, serum, Antibody titer, nasal swab, respiratory, seropositive, Evidence, Vaccination strategy, Middle East, evidence of, zoonotic transmission, MERS-CoV infection, virus RNA, coronavirus RNA, Complete, rectal swab, Prevent, tested, significant increases in, 【제목키워드】 Coronavirus infection, Saudi Arabia, longitudinal study, respiratory, Middle East,