ABSTRACT We studied plasma antibody responses of 35 patients about 1 month after SARS-CoV-2 infection. Titers of antibodies binding to the viral nucleocapsid and spike proteins were significantly higher in patients with severe disease. Likewise, mean antibody neutralization titers against SARS-CoV-2 pseudovirus and live virus were higher in the sicker patients, by ∼5-fold and ∼7-fold, respectively. These findings have important implications for those pursuing plasma therapy, isolation of neutralizing monoclonal antibodies, and determinants of immunity.
All Keywords
【저자키워드】 SARS-CoV-2, antibody, neutralization, severe, Non-severe, 【초록키워드】 therapy, Immunity, SARS-COV-2 infection, Spike protein, titer, response, Patient, Isolation, plasma, SARS-CoV-2 pseudovirus, patients, Antibody neutralization, Live virus, neutralizing monoclonal antibodies, severe disease, determinant, plasma antibody, antibodies binding, implication, significantly higher, the viral nucleocapsid, 【제목키워드】 response, Patient, SARS-CoV-2 neutralizing antibody, severe disease, robust,
【저자키워드】 SARS-CoV-2, antibody, neutralization, severe, Non-severe, 【초록키워드】 therapy, Immunity, SARS-COV-2 infection, Spike protein, titer, response, Patient, Isolation, plasma, SARS-CoV-2 pseudovirus, patients, Antibody neutralization, Live virus, neutralizing monoclonal antibodies, severe disease, determinant, plasma antibody, antibodies binding, implication, significantly higher, the viral nucleocapsid, 【제목키워드】 response, Patient, SARS-CoV-2 neutralizing antibody, severe disease, robust,