ABSTRACT The novel coronavirus (2019-nCoV) infection caused pneumonia. we retrospectively analyzed the virus presence in the pharyngeal swab, blood, and the anal swab detected by real-time PCR in the clinical lab. Unexpectedly, the 2109-nCoV RNA was readily detected in the blood (6 of 57 patients) and the anal swabs (11 of 28 patients). Importantly, all of the 6 patients with detectable viral RNA in the blood cohort progressed to severe symptom stage, indicating a strong correlation of serum viral RNA with the disease severity ( p -value = 0.0001). Meanwhile, 8 of the 11 patients with annal swab virus-positive was in severe clinical stage. However, the concentration of viral RNA in the anal swab (Ct value = 24 + 39) was higher than in the blood (Ct value = 34 + 39) from patient 2, suggesting that the virus might replicate in the digestive tract. Altogether, our results confirmed the presence of virus RNA in extra-pulmonary sites.
【저자키워드】 2019-nCoV, anal swab, Laboratory test, Pharyngeal swab, blood viral RNA, 【초록키워드】 Pneumonia, severity, Infection, Symptom, virus, Novel coronavirus, RNA, serum, Cohort, Real-time PCR, Patient, Viral RNA, Swab, correlation, patients, Blood, Concentration, digestive tract, virus RNA, lab, analyzed, caused, detectable, the disease, replicate, progressed, 【제목키워드】 Viral RNA, Blood, Clinical severity,