Background COVID-19 associated acute respiratory distress syndrome (CARDS) is a severe form of SARS CoV-2 infection and affects about 15–30% of hospitalized patients with a high mortality rate. Growing research and data suggest several available drugs with appropriate pharmacological effects to treat COVID-19. Main body Prostacyclin analogues are regiments for pulmonary artery hypertension. Prostacyclin analogues are expected to be beneficial in treating CARDS based on at least four rationales: (1) inhaled prostacyclin analogues improve oxygenation, V / Q mismatch, and act as an ARDS therapy alternative; (2) it alleviates direct SARS-CoV-2-related coagulopathy; (3) increases nitric oxide production; and (4) possible anti-inflammatory effect. Prostacyclin analogues are available in oral, intravenous, and inhaled forms. The inhaled form has the advantage over other forms, such as parenteral administration risks. Previously, a meta-analysis demonstrated the beneficial effects of inhaled prostaglandins for ARDS treatment, such as improved PaO2/FiO2 and PaO2 along with reduced pulmonary artery pressure. Currently, two ongoing randomized controlled trials are evaluating inhaled epoprostenol (VPCOVID [NCT04452669]) and iloprost (ILOCOVID [NCT04445246]) for severe COVID-19 patients. Conclusions Inhaled prostacyclin could be considered in patients with refractory, life-threatening hypoxia despite standard management.
【저자키워드】 COVID-19, ARDS, prostacyclin, Epoprostenol, 【초록키워드】 Randomized controlled trial, SARS CoV-2, Treatment, Meta-analysis, therapy, hypoxia, nitric oxide, Infection, drug, hypertension, management, Research, Patient, Inhaled, acute respiratory distress, Oxygenation, intravenous, pulmonary artery pressure, paO2/fiO2, PaO2, syndrome, severe COVID-19 patients, life-threatening, treat, anti-inflammatory effect, high mortality rate, forms, pharmacological, analogue, Effect, Affect, parenteral administration, IMPROVE, reduced, increase, hospitalized patient, demonstrated, expected, alleviate, 【제목키워드】 acute respiratory distress, analogue,