Abstract Purpose To investigate the diagnostic accuracy of a different sample preparation protocol for fine needle aspiration cytology (FNAC) of thyroid nodules established during the COVID‐19 pandemic. Methods From April 2020, conventional smears during FNAC were ceased according to World Health Organization recommendations due to the increased infection risk for operators, and a new protocol using only liquid‐based cytology (LBC) was adopted. FNACs performed between April and July 2020 (COVID‐19 group) were retrospectively compared with those from December 2019 through March 2020 (Pre‐COVID‐19 group). The distribution of diagnoses based on SIAPEC‐IAP categories and the concordance between cytological and histological results were compared using the chi‐squared test. Results Categories based on FNAC for 90 and 82 thyroid nodules in the Pre‐COVID‐19 and COVID‐19 groups showed no significant difference in distribution ( P = .081), with the following respective cases (and percentages): TIR1, 7 (8%) and 8 (10%); TIR1C, 0 (0%) and 6 (7%); TIR2, 59 (66%) and 55 (67%); TIR3A, 8 (9%) and 5 (6%); TIR3B, 1 (1%) and 2 (3%); TIR4, 5 (6%) and 1 (1%); and TIR5, 10 (12%) and 5 (7%). Among patients with potentially malignant lesions, surgery was performed for 12/16 (75%) nodules in the Pre‐COVID‐19 and 7/8 (88%) nodules in the COVID‐19 groups, with no significant differences between cytological and histological diagnoses ( P = .931). Conclusion The new LBC‐only protocol provided similar diagnostic accuracy in comparison with conventional smears, and can be effectively applied during a viral pandemic improving operator safety. The aim of this work was to investigate the diagnostic accuracy of a new sample preparation protocol for FNAC of thyroid nodules established during the COVID‐19 pandemic and to compare it with the diagnostic accuracy of the previously established standard protocol.
【저자키워드】 COVID‐19, surgery, Thyroid, cytology, fine needle aspiration, 【초록키워드】 pandemic, protocol, diagnostic, COVID‐19, Concordance, Accuracy, Patient, infection risk, group, distribution, diagnose, World Health Organization, no significant difference, lesions, nodule, operator, operators, recommendation, cytological, Result, performed, provided, applied, was performed, adopted, category, groups, histological, 【제목키워드】 pandemic, COVID‐19, change,