Gilbert syndrome (GS) is a liver disorder characterized by non-hemolytic unconjugated hyperbilirubinemia. On the other hand, Coronavirus disease 2019 (Covid-19) is a recent viral infectious disease presented as clusters of pneumonia, triggered by the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). Little is known on the association between SARS-CoV-2 and GS, despite different studies have recently stated a link between hyperbilirubinemia and SARS-CoV-2 severity. In this case-report study we described a 47-year-old man, a known case of GS since the age of 4, presented to the emergency department with fever (39.8°C), dry cough, dyspnea, headache, myalgia, sweating and jaundice diagnosed with Covid-19-induced pneumonia. Interestingly, GS patient exhibited a rapid clinical recovery and short hospital stay compared to other SARS-CoV-2 positive patient, seeming that hyperbilirubinemia may exert a protective effect of against Covid-19 induced-cardiometabolic disturbances. Data obtained here underlines that the higher resistance against Covid-19 evidenced by the GS patient seems to be due to the antioxidant, anti-inflammatory, and antiviral effects of unconjugated bilirubin.
【저자키워드】 COVID-19, SARS-CoV-2, metabolic disease, hyperbilirubinemia, gilbert syndrome, 【초록키워드】 Coronavirus disease 2019, Anti-inflammatory, Pneumonia, severity, headache, antioxidant, Antiviral effect, clinical recovery, Fever, Dyspnea, Patient, Cluster, age, liver, protective effect, association, myalgia, Hospital stay, dry cough, disorder, positive, jaundice, viral infectious disease, sweating, described, diagnosed, exhibited, characterized, triggered, evidenced, unconjugated bilirubin, 【제목키워드】 metabolic, disturbance,