There are few detailed investigations of neurologic complications in severe acute respiratory syndrome coronavirus 2 infection. We describe 3 patients with laboratory-confirmed coronavirus disease who had encephalopathy and encephalitis develop. Neuroimaging showed nonenhancing unilateral, bilateral, and midline changes not readily attributable to vascular causes. All 3 patients had increased cerebrospinal fluid (CSF) levels of anti-S1 IgM. One patient who died also had increased levels of anti-envelope protein IgM. CSF analysis also showed markedly increased levels of interleukin (IL)-6, IL-8, and IL-10, but severe acute respiratory syndrome coronavirus 2 was not identified in any CSF sample. These changes provide evidence of CSF periinfectious/postinfectious inflammatory changes during coronavirus disease with neurologic complications.
【저자키워드】 COVID-19, coronavirus disease, severe acute respiratory syndrome coronavirus 2, viruses, respiratory infections, zoonoses, SARS-CoV-2, Coronaviruses, Cytokines, Encephalitis, Georgia, serologic analysis, Encephalopathy, cerebrospinal fluid, United States, CSF, Atlanta, meningitis/encephalitis, 【초록키워드】 IgM, coronavirus, Infection, Protein, Patient, Neuroimaging, IL-8, Complication, complications, IL-10, change, Evidence, acute respiratory syndrome, Vascular, causes, one patient, anti-S1 IgM, laboratory-confirmed, neurologic, CSF analysis, develop, died, inflammatory change, 【제목키워드】 USA, alteration,