Background Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a virus that causes COVID-19, which has become a worldwide pandemic. However, until now, there is no vaccine or specific drug to prevent or treat COVID-19. Objectives To find out the effective treatment as an antiviral agent for COVID-19, to determine the correlation between sociodemography with clinical outcomes and duration of treatment, and to determine the relationship between comorbidities with clinical outcomes and duration of treatment for COVID-19 patients. Methods A prospective cohort study was conducted in this study. This study included only confirmed COVID-19 patients who were admitted to the hospital during April-May 2020. Convenience sampling was used to select 103 patients, but only 72 patients were suitable for inclusion. Results The survival analysis for COVID-19 patients using the Kaplan Meier method showed that patients receiving Oseltamivir + Hydroxychloroquine had an average survival rate of about 83% after undergoing treatment of about ten days. Gender (p = 0.450) and age (p = 0.226) did not have a significant correlation with the duration of treatment for COVID-19 patients. Gender (p = 0.174) and age (p = 0.065) also did not have a significant correlation with clinical outcome of COVID-19 patients. Comorbidities showed a significant correlation with duration of treatment (p = 0.002) and clinical outcome (p = 0.014) of COVID-19 patients. Conclusion The most effective antiviral agent in this study based on treatment duration was the combination of Oseltamivir + Hydroxychloroquine. The higher the patient’s average treatment duration is, the lower the average survival rate for COVID-19 patients.
【초록키워드】 COVID-19, Treatment, SARS-CoV-2, Vaccine, oseltamivir, Hydroxychloroquine, Antiviral, hospital, Comorbidities, Comorbidity, severe acute respiratory syndrome coronavirus-2, prospective cohort study, virus, clinical outcomes, Clinical outcome, survival, Patient, age, survival rate, respiratory, correlation, antiviral agent, patients, COVID-19 patients, Combination, Analysis, survival analysis, COVID-19 patient, convenience sampling, duration of treatment, worldwide pandemic, average, treat, convenience, objective, Prevent, effective, Result, was used, conducted, receiving, determine, cause, for inclusion, treatment for COVID-19, 【제목키워드】 hospital, COVID-19 patient, profile, Jakarta,