An ongoing pandemic of coronavirus disease (COVID-19) is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Characterization of the histopathology and cellular localization of SARS-CoV-2 in the tissues of patients with fatal COVID-19 is critical to further understand its pathogenesis and transmission and for public health prevention measures. We report clinicopathologic, immunohistochemical, and electron microscopic findings in tissues from 8 fatal laboratory-confirmed cases of SARS-CoV-2 infection in the United States. All cases except 1 were in residents of long-term care facilities. In these patients, SARS-CoV-2 infected epithelium of the upper and lower airways with diffuse alveolar damage as the predominant pulmonary pathology. SARS-CoV-2 was detectable by immunohistochemistry and electron microscopy in conducting airways, pneumocytes, alveolar macrophages, and a hilar lymph node but was not identified in other extrapulmonary tissues. Respiratory viral co-infections were identified in 3 cases; 3 cases had evidence of bacterial co-infection.
【저자키워드】 COVID-19, 2019 novel coronavirus disease, coronavirus disease, severe acute respiratory syndrome coronavirus 2, viruses, respiratory infections, zoonoses, SARS-CoV-2, immunohistochemistry, pathology, coronavirus, Histopathology, electron microscopy, Diffuse alveolar damage, 【초록키워드】 pandemic, Pathogenesis, SARS-COV-2 infection, Infection, Transmission, Measures, Microscopy, Patient, Co-infection, respiratory, Care, Critical, bacterial co-infection, patients, extrapulmonary tissues, cellular, Evidence, Pneumocytes, Lymph node, airways, Alveolar macrophages, characterization, acute respiratory syndrome, tissue, fatal COVID-19, laboratory-confirmed, The United States, caused, detectable, lower airway, predominant pulmonary pathology, public health prevention, 【제목키워드】 United State,