Virus shedding in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can occur before onset of symptoms; less is known about symptom progression or infectiousness associated with initiation of viral shedding. We investigated household transmission in 5 households with daily specimen collection for 5 consecutive days starting a median of 4 days after symptom onset in index patients. Seven contacts across 2 households implementing no precautionary measures were infected. Of these 7, 2 tested positive for SARS-CoV-2 by reverse transcription PCR on day 3 of 5. Both had mild, nonspecific symptoms for 1–3 days preceding the first positive test. SARS-CoV-2 was cultured from the fourth-day specimen in 1 patient and from the fourth- and fifth-day specimens in the other. We also describe infection control measures taken in the households that had no transmission. Persons exposed to SARS-CoV-2 should self-isolate, including from household contacts, wear a mask, practice hand hygiene, and seek testing promptly.
【저자키워드】 COVID-19, coronavirus disease, severe acute respiratory syndrome coronavirus 2, viruses, respiratory infections, zoonoses, SARS-CoV-2, SARS virus, Virus shedding, reverse transcription PCR, 【초록키워드】 infection control, coronavirus, viral shedding, Transmission, Symptom, progression, Patient, Mild, household transmission, patients, household contacts, Contact, hygiene, symptom onset, acute respiratory syndrome, specimen, measure, positive, self-isolate, first positive, tested, were infected, investigated, median, less, occur, had no, nonspecific, Person, 【제목키워드】 coronavirus 2, shedding, respiratory, USA, Utah,