Israel experienced a new wave of coronavirus disease during June 2021, six months after implementing a national vaccination campaign. We conducted 3 discrete analyses using data from a large health maintenance organization in Israel to determine whether IgG levels of fully vaccinated persons decrease over time, describe the relationship between IgG titer and subsequent PCR-confirmed infection, and compare PCR-confirmed infection rates by period of vaccination. Mean IgG levels steadily decreased over the 6-month period in the total tested population and in all age groups. An inverse relationship was found between IgG titer and subsequent PCR-positive infection. Persons vaccinated during the first 2 months of the campaign were more likely to become infected than those subsequently vaccinated. The vaccinated group > 60 years of age had lower initial IgG levels and were at greater risk for infection. The findings support the decision to add a booster vaccine for persons > 60 years of age.
【저자키워드】 COVID-19, coronavirus disease, severe acute respiratory syndrome coronavirus 2, viruses, respiratory infections, zoonoses, public health, SARS-CoV-2, Coronaviruses, immune response, vaccination, Vaccines, Epidemiology, mRNA BNT162b2 vaccine, infections, Israel, serologic tests, Health Maintenance Organization, HMO, 【초록키워드】 IgG, Infection, risk, Health, age, infection rate, Booster vaccine, Support, PCR-confirmed, PCR-positive, all age groups, National, decrease, initial, greater, tested, subsequent, conducted, determine, analysis, IgG level, Person, steadily decreased, 【제목키워드】 organization, mRNA BNT162b2, maintenance, Month,