Background The clinical significance of the quantitative value of antibodies in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remains mostly unidentified. We investigated the dynamics and clinical implications of the SARS-CoV-2 antibody over time using three automated chemiluminescence immunoassays targeting either nucleocapsids or spikes. Methods A total of 126 specimens were collected from 23 patients with confirmed and indeterminate COVID-19 identified by molecular tests. SARS-CoV-2 antibody index was measured using SARS-CoV2 IgG reagent from Alinity (Abbott) and Access (Beckman Coulter) and SARS-CoV2 Total (IgG + IgM) from Atellica (Siemens). Results Three immunoassays showed strong correlations with each other (range of Pearson’ s correlation coefficient (r) = 0.700–0.854, P < 0.001). Eleven (8.7%) specimens showed inconsistencies. SARS-CoV-2 IgG showed a statistically significantly higher value in patients with severe disease than that in non-severe disease patients ( P < 0.001) and was significantly associated with clinical markers of disease severity. Conclusion The quantitative value of the SARS-CoV-2 IgG antibody measured using automated immunoassays is a significant indicator of clinical severity in patients with COVID-19.
【초록키워드】 COVID-19, SARS-CoV-2, IgG, IgM, coronavirus, SARS-CoV2, antibody, disease severity, Infection, severe acute respiratory syndrome Coronavirus, immunoassay, IgG antibody, SARS-CoV-2 antibody, nucleocapsid, SARS-CoV-2 IgG antibody, chemiluminescence immunoassay, Patient, Clinical significance, access, automated, respiratory, correlation, disease, Quantitative, SARS-CoV-2 IgG, Molecular tests, Clinical severity, severe disease, Abbott, (Abbott, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, spikes, specimen, clinical markers, Siemens, correlation coefficient, Beckman Coulter, clinical implications, nucleocapsids, Result, was measured, collected, significantly, investigated, significantly higher, Total, statistically, clinical implication, clinical marker, patients with COVID-19, the SARS-CoV-2, 【제목키워드】 SARS-CoV-2, antibody, chemiluminescence immunoassay, serological,