Emerging coronaviruses are a global public health threat because of the potential for person-to-person transmission and high mortality rates. Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012, causing lethal respiratory disease in »35% of cases. Primate models of coronavirus disease are needed to support development of therapeutics, but few models exist that recapitulate severe disease. For initial development of a MERS-CoV primate model, 12 African green monkeys were exposed to 10 3 , 10 4 , or 10 5 PFU target doses of aerosolized MERS-CoV. We observed a dose-dependent increase of respiratory disease signs, although all 12 monkeys survived for the 28-day duration of the study. This study describes dose-dependent effects of MERS-CoV infection of primates and uses a route of infection with potential relevance to MERS-CoV transmission. Aerosol exposure of African green monkeys might provide a platform approach for the development of primate models of novel coronavirus diseases.
【저자키워드】 COVID-19, coronavirus disease, severe acute respiratory syndrome coronavirus 2, viruses, respiratory infections, zoonoses, SARS-CoV-2, SARS-CoV, MERS, MERS-CoV, Model, Middle East respiratory syndrome, Medical countermeasures, primate, 【초록키워드】 coronavirus, Diseases, Transmission, aerosol, Novel coronavirus, Respiratory disease, African green monkey, platform, dose, severe disease, Middle East, Support, route of infection, global public health, high mortality, respiratory syndrome coronavirus, MERS-CoV infection, approach, MERS-CoV transmission, initial, dose-dependent, survived, dose-dependent effect, 【제목키워드】 aerosol, Particle, African, exposure, Monkey, green,