Resolving the role of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission in households with members from different generations is crucial for containing the current pandemic. We conducted a large-scale, multicenter, cross-sectional seroepidemiologic household transmission study in southwest Germany during May 11–August 1, 2020. We included 1,625 study participants from 405 households that each had ≥1 child and 1 reverse transcription PCR–confirmed SARS-CoV-2–infected index case-patient. The overall secondary attack rate was 31.6% and was significantly higher in exposed adults (37.5%) than in children (24.6%–29.2%; p = < 0.015); the rate was also significantly higher when the index case-patient was > 60 years of age (72.9%; p = 0.039). Other risk factors for infectiousness of the index case-patient were SARS-CoV-2–seropositivity (odds ratio [OR] 27.8, 95% CI 8.26–93.5), fever (OR 1.93, 95% CI 1.14–3.31), and cough (OR 2.07, 95% CI 1.21–3.53). Secondary infections in household contacts generate a substantial disease burden.
【저자키워드】 COVID-19, coronavirus disease, severe acute respiratory syndrome coronavirus 2, viruses, respiratory infections, zoonoses, antibodies, SARS-CoV-2, serology, children, Transmission, Households, 【초록키워드】 coronavirus, pandemic, cross-sectional, risk factor, cough, secondary attack rate, Secondary infection, Germany, Fever, household transmission, age, reverse transcription, household contact, multicenter, Other, disease, Odds ratio, acute respiratory syndrome, 95% CI, generate, conducted, significantly higher, study participant, 【제목키워드】 coronavirus 2, household, Germany, respiratory,