Virus is associated with respiratory tract disease in children <5 years of age. In 2005, a new human coronavirus, HCoV-HKU1, was identified in Hong Kong. We screened respiratory specimens collected from December 16, 2001, to December 15, 2002, from children <5 years of age who tested negative for respiratory syncytial virus, parainfluenza viruses, influenza virus, and adenovirus for HCoV-HKU1 by reverse transcription–polymerase chain reaction. Overall, 1,048 respiratory specimens from 851 children were tested, and 9 HCoV-HKU1–positive children (1%) were identified, 2 of whom had 2 positive specimens. Children who had HCoV-HKU1 infection had evidence of either upper or lower respiratory tract infection or both. Two patients had disease beyond the respiratory tract. HCoV-HKU1 was identified from December 2001 to February 2002. Sequence analyses suggest that a single strain was circulating. HCoV-HKU1 is therefore likely circulating in the United States and is associated with upper and lower respiratory tract disease.
【저자키워드】 respiratory infections, Coronaviruses, HCoV-HKU1, Clinical features, Coronavirus HKU1, 【초록키워드】 viruses, coronavirus, children, Infection, HCoV-HKU1, Influenza virus, Adenovirus, respiratory syncytial virus, age, respiratory tract, Hong Kong, disease, specimens, HKU1, Evidence, parainfluenza, Lower respiratory tract, circulating, positive, tested, respiratory specimen, collected, the United State, screened, Two patient, analysis,