Many important questions remain regarding severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the viral pathogen responsible for COVID-19. These questions include the mechanisms explaining the high percentage of asymptomatic but highly infectious individuals, the wide variability in disease susceptibility, and the mechanisms of long-lasting debilitating effects. Bioinformatic analysis of four coronavirus datasets representing previous outbreaks (SARS-CoV-1 and MERS-CoV), as well as SARS-CoV-2, revealed evidence of diverse host factors that appear to be coopted to facilitate virus-induced suppression of interferon-induced innate immunity, promotion of viral replication and subversion and/or evasion of antiviral immune surveillance. These host factors merit further study given their postulated roles in COVID-19-induced loss of smell and brain, heart, vascular, lung, liver, and gut dysfunction.
【초록키워드】 COVID-19, SARS-CoV-2, coronavirus, Antiviral, Innate immunity, susceptibility, interferon, lung, severe acute respiratory syndrome Coronavirus, SARS-CoV-1, MERS-CoV, immune, Brain, Severe acute respiratory syndrome, Viral, Asymptomatic, Surveillance, outbreak, viral replication, heart, dataset, respiratory, disease, liver, mechanism, Coronavirus-2, Evidence, Analysis, Bioinformatic, Gut, evidence of, disease susceptibility, immune surveillance, dysfunction, Loss of Smell, acute respiratory syndrome, Factor, Vascular, acute respiratory syndrome coronavirus, Variability, acute respiratory syndrome coronavirus-2, promotion, viral pathogen, bioinformatic analysis, subversion, Host, Effects, responsible, include, facilitate, question, long-lasting, representing, individuals, 【제목키워드】 COVID-19, therapeutic target, identify,