Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause coronavirus disease 2019 (COVID-19). Most individuals recover from SARS-CoV-2 infection, however, many continue to experience a cluster of persistent symptoms for months following resolution of acute disease; a syndrome that has been named Long-COVID. While the biological cause, or causes, of Long-COVID have not yet been confirmed, the main proposals have centred around either virus-induced autoimmunity or virus-induced tissue dysfunction. However, an alternative suggestion that a latent chronic infection could be responsible for the symptoms of Long-COVID has received minimal attention despite recent findings that SARS-CoV-2 genetic material and infections are detected in some individuals months following resolution of respiratory disease. Here we discuss literature supporting the possibility that Long-COVID occurs as a result of chronic SARS-CoV-2 infections.
【저자키워드】 COVID-19, immunology, chronic, gut flora, Long-COVID-syndrome, 【초록키워드】 coronavirus disease, SARS-CoV-2, Autoimmunity, coronavirus, SARS-COV-2 infection, Infection, Symptom, Respiratory disease, Cluster, SARS-CoV-2 infections, chronic infection, dysfunction, acute respiratory syndrome, tissue, causes, individual, syndrome, genetic material, while, MOST, responsible, occur, recent finding, 【제목키워드】 SARS-CoV-2, cause,