In the past two decades, coronavirus (CoV) has emerged frequently in the population. Three CoVs (SARS-CoV, MERS-CoV, SARS-CoV-2) have been identified as highly pathogenic human coronaviruses (HP-hCoVs). Particularly, the ongoing COVID-19 pandemic caused by SARS-CoV-2 warns that HP-hCoVs present a high risk to human health. Like other viruses, HP-hCoVs interact with their host cells in sophisticated manners for infection and pathogenesis. Here, we reviewed the current knowledge about the interference of HP-hCoVs in multiple cellular processes and their impacts on viral infection. HP-hCoVs employed various strategies to suppress and evade from immune response, including shielding viral RNA from recognition by pattern recognition receptors (PRRs), impairing IFN-I production, blocking the downstream pathways of IFN-I, and other evasion strategies. This summary provides a comprehensive view of the interplay between HP-hCoVs and the host cells, which is helpful to understand the mechanism of viral pathogenesis and develop antiviral therapies.
【저자키워드】 SARS-CoV-2, Innate immunity, Host–virus interaction, highly pathogenic coronaviruses, IFN signaling pathway, 【초록키워드】 viruses, viral infection, coronavirus, immune response, Pathogenesis, SARS-CoV, knowledge, COVID-19 pandemic, viral pathogenesis, Infection, MERS-CoV, Health, Impact, pathway, IFN-I, CoV, Viral RNA, mechanism, pattern recognition receptor, high risk, host cells, host cell, antiviral therapies, shielding, PRRs, comprehensive view, downstream, highly pathogenic, human coronavirus, develop, caused, provide, Like, evade, suppress, cellular processe, impairing, 【제목키워드】 SARS-CoV, Strategy, MERS-CoV, Innate,