Like other RNA viruses, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replicates in host cells, continuously modulating the molecular environment. It encodes 28 multifunctional proteins that induce an imbalance in the metabolic and proteostatic homeostasis in infected cells. Recently, proteomic approaches have allowed the evaluation of the impact of SARS-CoV-2 infection in human cells. Here, we discuss the current use of proteomics in three major application areas: (i) virus-protein interactomics, (ii) differential proteotyping to map the virus-induced changes in different cell types, and (iii) diagnostic methods for coronavirus infectious disease 2019 (COVID-19). Since the nasal cavity is one of the entry sites for SARS-CoV-2, we will also discuss the potential application of olfactory proteomics to provide novel insights into the olfactory dysfunction triggered by SARS-CoV-2 in patients with COVID-19.
【저자키워드】 proteomics, severe acute respiratory syndrome coronavirus-2, Smell, Coronavirus infectious disease 2019, mass-spectrometry, 【초록키워드】 COVID-19, SARS-CoV-2, coronavirus, SARS-COV-2 infection, nasal, Infectious disease, olfactory dysfunction, RNA viruses, molecular, homeostasis, proteomic, Diagnostic method, olfactory, cell types, host cells, acute respiratory syndrome, infected cells, human cells, ENCODE, multifunctional protein, approach, replicate, changes in, Like, induce, triggered, modulating, patients with COVID-19, 【제목키워드】 SARS-CoV-2, Human, axis, insight, Basis, Can,