Background Serological response and association to clinical manifestation is important for understanding the pathogenesis of COVID-19. Materials and methods A prospective observational study was conducted where antibody responses of IgG and IgA towards SARS-CoV-2 spike protein were studied over time in patients with COVID-19. Possible associations between antibody titers and outcome were analyzed. Results Forty patients with COVID-19, hospitalized at Skåne University hospital, Sweden, between April and June 2020 were included. IgG antibody responses were detected for all patients with the highest levels four weeks after COVID-19 diagnosis. Levels of IgA were generally higher at diagnosis and decreased towards baseline 4 weeks after confirmed COVID-19. Patients with severe COVID-19 had higher levels of antibodies directed against SARS-CoV-2 spike protein compared with patients with mild disease. Conclusion IgG and IgA antibodies towards the spike protein follow different kinetics during COVID-19 and patients with severe disease develop higher antibody levels.
【초록키워드】 COVID-19, IgG, Pathogenesis, Hospitalized, severe COVID-19, antibody, prospective observational study, hospital, Antibody Response, Diagnosis, outcome, observational study, Spike protein, Antibody responses, IgG antibody, IgA, response, SARS-CoV-2 spike protein, Patient, COVID-19 diagnosis, Antibody titer, university, Antibody titers, Mild disease, association, severe disease, clinical manifestation, IgA antibodies, pathogenesis of COVID-19, material, Result, highest, analyzed, develop, conducted, the spike protein, Level, IgA antibody, baseline, levels of antibody, patients with COVID-19, with mild disease, 【제목키워드】 COVID-19, Clinical course,