Emerging coronaviruses (CoV) are constant global public health threats to society. Multiple ongoing clinical trials for vaccines and antivirals against CoVs showcase the availability of medical interventions to both prevent and treat the future emergence of highly pathogenic CoVs in human. However, given the diverse nature of CoVs and our close interactions with wild, domestic and companion animals, the next epidemic zoonotic CoV could resist the existing vaccines and antivirals developed, which are primarily focused on Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS CoV). In late 2019, the novel CoV (SARS-CoV-2) emerged in Wuhan, China, causing global public health concern. In this review, we will summarize the key advancements of current vaccines and antivirals against SARS-CoV and MERS-CoV as well as discuss the challenge and opportunity in the current SARS-CoV-2 crisis. At the end, we advocate the development of a “plug-and-play” platform technologies that could allow quick manufacturing and administration of broad-spectrum countermeasures in an outbreak setting. We will discuss the potential of AAV-based gene therapy technology for in vivo therapeutic antibody delivery to combat SARS-CoV-2 outbreak and the future emergence of severe CoVs.
【저자키워드】 Vaccine, antivirals, 2019 nCoV, Coronavirus (CoV), adeno-associate virus, passive immunization strategy, MERS- and SARS-CoV, 【초록키워드】 SARS-CoV-2, clinical trial, Antiviral, antibody, SARS-CoV, threat, MERS, MERS-CoV, Gene therapy, Epidemic, outbreak, zoonotic, therapeutic, CoV, respiratory, in vivo, platform, Interaction, administration, Middle East, global public health, CoVs, treat, Multiple, medical intervention, Prevent, Wuhan, China, coronavirus, against SARS-CoV, highly pathogenic CoV, 【제목키워드】 Future, state, current, Against,