Background Coronavirus disease 2019 (COVID-19) is a serious illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and in severe cases associated with acute respiratory distress syndrome (ARDS). Objective To describe the clinical characteristics of patients with ARDS-COVID-19. Materials and methods This study involved 197 male Egyptian participants, among them111 COVID-19 patients presented with ARDS, 60 COVID-19 patients presented with non-ARDS, and 26 Non-COVID-19 patients. We reported the analysis results of clinical and laboratory information, including blood routine tests, blood biochemistry parameters [aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine and C‐reactive protein (CRP)], thrombotic activity (D‐dimer) and serum ferritin and lactate dehydrogenase (LDH). Results The levels of hemoglobin, AST, creatinine, monocyte count, monocyte %, RBC count, TLC, and platelet count were not significantly different among the groups. The lymphopenia and increased CRP, ALT, D-dimer, ferritin, and LDH were observed in patients with ARDS-COVID-19. Conclusion COVID-19 patients with ARDS presented with lymphopenia, increased thrombotic activity, increased CRP, LDH, and ferritin levels. The results revealed that CRP, D-dimer, LDH levels, and lymphopenia have a significant association with the COVID-19 severity and can be used as biomarkers to predict the disease severity.
【초록키워드】 COVID-19, coronavirus disease, SARS-CoV-2, Coronavirus disease 2019, ARDS, coronavirus, Biomarker, Biomarkers, acute respiratory distress syndrome, Clinical characteristics, severity, disease severity, COVID-19 severity, LDH, CRP, D-dimer, ferritin, severe acute respiratory syndrome Coronavirus, lactate dehydrogenase, Laboratory, monocyte, lymphopenia, male, Patient, severe cases, Aspartate aminotransferase, Platelet, AST, hemoglobin, respiratory, information, patients, predict, Platelet count, association, acute respiratory distress, ALT, Lactate, creatinine, Analysis, D‐dimer, COVID-19 patient, respiratory distress, alanine aminotransferase, Serum ferritin, acute respiratory syndrome, Participants, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, syndrome, aspartate, ferritin levels, thrombotic, Alanine, Blood routine, Severe case, blood biochemistry, material, C‐reactive protein, parameter, monocyte count, RBC count, objective, RBC, Result, caused, involved, reported, the disease, can be used, groups, not significantly different, 【제목키워드】 COVID‐19, Characteristics, clinical, male, Patient, acute respiratory distress, syndrome,